Metabolism 101: Tutorial 1 - Introduction to metabolism

For the non-metabolic | taught by Georgianne Arnold
  • 43 Videos
  • 7 Quizzes
  • 1 Survey
  • 1 Text
  • 1 PDF
  • 0.8 hrs

Course Curriculum

Course Introduction/Objectives
Course Introduction and Objectives FREE TRIAL
Hide Content
Pre-Course Assessment
Pre-Course Assessment
Hide Content
Chapter 1: Introduction
Why Think Metabolic?
Take Home Point #1
Typical Metabolic History and Exam
Hide Content
Chapter 2: Classification of Metabolic Disorders
Classification of Metabolic Disorders
Hide Content
Chapter 3: Intoxication & Energy Metabolism: Protein
Basic Intermediary Metabolism: Protein
Anatomy of an Amino Acid and Catabolism
The Metabolic Geneticist's Rule and Take Home Point #2
Organic Acid Metabolic Defects
Take Home Point #3
Roadmap: Intermediary Metabolism of Protein
Hide Content
Chapter 4: Intoxication & Energy Metabolism: Carbohydrates
Basic Intermediary Metabolism: Carbohydrates
Defects in CHO metabolism
Take Home Point #3 (Updated)
Hide Content
Chapter 5: Intoxication & Energy Metabolism: Fatty Acid Oxidation Disorders
Basic Intermediary Metabolism: Fatty Acid Oxidation Disorders
Defects in Fatty Acid Metabolism
Take Home Point #4
Roadmap: Intermediary Metabolism
Disorder Characteristics: Intoxication & Energy Metabolism
Example: PDH Deficiency MRI
Intermediary Metabolism Disorders: Summary
Hide Content
Chapter 6: Disorders of Complex Molecules
Defects in Complex Molecules
Lysosomal Storage Disorders
Peroxisomal Disorders
Golgi/Endoplasmic Reticulum Disorders
Dysmorphology in Metabolic Disorders
Example: Smith-Lemli-Opitz Syndrome
Example: Zellweger Syndrome
Disorder Characteristics
Hide Content
Case Study 1
Case Study 1 Scenario
Case Study 1 Question
Case Study 1 Analysis
Hide Content
Case Study 2
Case Study 2 Scenario
Case Study 2 Question
Case Study 2 Analysis
Case Study 2 Follow-up Question
Case Study 2 Follow-up Analysis
Hide Content
Case Study 3
Case Study 3 Scenario
Case Study 3 Question
Case Study 3 Analysis
Hide Content
Case Study 4
Case Study 4 Scenario
Case Study 4 Question
Case Study 4 Analysis
Hide Content
Case Study 5
Case Study 5 Scenario
Case Study 5 Question
Case Study 5 Analysis
Hide Content
Patient-as-teacher video
Patient-as-Teacher Video: PDH Deficiency
Hide Content
Essential Slides for Download
Metabolism 101 Tutorial 1 Essential Slides (pdf)
Hide Content
Post Lecture Quiz
Hide Content
eLearning Course Survey
Course survey link
Hide Content

Course description

Course Title:

Metabolism 101: Introduction to Metabolism for the Non-Metabolic

Program Overview:

This introductory tutorial outlines a classification system for grouping and understanding the inborn errors. Many disorders of basic intermediary metabolism (disorders of protein, carbohydrate and fatty acid metabolism), and the metabolism of complex molecules (e.g., lysosomal storage diseases) are introduced here, showing how they fit into the classification scheme. Interactive case studies allow users to develop the skills to properly recognize and classify common metabolic disorders and identify treatable disorders.


Georgianne Arnold, MD - Associate Medical Director - Genetic Metabolic Center for Education

Credit Hours:

1.0 AMA PRA Category 1 Credit

Important Dates:

Valid Until: 12/01/2019
Date Released: 12/01/2016
Date Updated: 12/01/2016

Fee Statement:

This activity if FREE to all participants

Commercial Support:

This enduring internet activity has no commercial support

Learning Objectives:

  1. Identify the reasons for “thinking metabolic” in clinical practice
  2. Develop a classification system for thinking about metabolic disease
  3. Recognize how defective intermediary metabolism results in disease

Accreditation Statement:

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Nemours and the Genetic Metabolic Center for Education. Nemours is accredited by the ACCME to provide continuing medical education for physicians.

Nemours designates this internet enduring activity for a maximum number of 1.0 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in this activity.

Disclosure Statement:

The information on this website is provided exclusively for educational purposes. Information about medicine is ever changing. As new research and clinical experience broadens knowledge, changes in treatment and procedures will be necessary. Nemours has consulted with sources believed to be reliable in order to provide information that is comprehensive and in accord with standards of care at the initial time of publication. However, Nemours disclaims any duty to update the information and encourages readers to do so. Nemours makes no warranties, either implied or expressed, that the information contained herein is accurate or complete. Nemours is not responsible for any errors or omissions with respect to the information or for the results obtained from the use of the information. Readers are encouraged to confirm the information with other sources.

Faculty Disclosure:

The listed speaker has no real or apparent conflict of interest to disclose.

Planning Committee Disclosure:

The members of the planning committee have no real or apparent conflict of interest to disclose.

Instruction for Completion:

To receive credit for this unit, view the video files and complete all survey questions. It will take approximately 60 minutes to complete. When you have finished, complete the post-test. Upon scoring at least 70% on the post-test and completion of the evaluation you will be able download your CME/CE certificate.

Clinicians who are not physicians will be provided a certificate of completion to submit for credit in accordance with their state nursing board, specialty society, or other professional association.

Additional Resources:

Inborn Metabolic Diseases, 5th Edition, Saudubray et al, eds. Springer Berlin Heidelberg, 2012
The Online Metabolic and Molecular Bases of Inherited Disease, Scriver et al, eds. McGraw-Hill

Read More


Georgianne Arnold
Georgianne Arnold
MD, Associate Medical Director

Dr. Georgianne Arnold is Associate Medical Director of the Genetic Metabolic Center for Education and is active in both the consultative servicesand educational programs.

Dr. Arnold previously served as Professor of Pediatrics as well as Clinical Director of the Division of Medical Genetics (2010 – 2016) at the University of Pittsburgh Medical Center. She brings 25 years of experience in the diagnosis and care of patients with inborn errors of metabolism. She has extensive experience in teaching including students, residents and faculty, and was a charter faculty member at the North American Metabolic Academy (the premier training conference for genetic trainees on this continent).

Dr. Arnold has published more than 50 peer reviewed articles and book chapters, has presented papers at national and international meetings, and was awarded the Shapira Award in 2010 for “A Delphi clinical practice protocol for the management of very long chain acyl-CoA dehydrogenase deficiency.” She is sought after as a teacher with a gift for making metabolism understandable for all audiences.

Dr. Arnold graduated from SUNY Upstate Medical University and and completed pediatric residency at Children’s Memorial Hospital at Nothwestern University. She completed her fellowship in genetics and metabolism in 1991 at the University of Colorado. She was Associate Professor of Pediatrics at the University of Rochester School of Medicine and Dentistry until 2010 where she directed care for patients with metabolic and genetic disorders.

Reviews (12)

by Naomi Alfonso

by William Stanford

by Nino Epitashvili
Read more

by Naomi Alfonso

by William Stanford

by Nino Epitashvili

Metabolism 101: Tutorial 1 - Introduction to metabolism

by Melissa Swaney
I found this information very useful

by Enrique Ponte

by Natara Joyner

Review of Tutorial

by Helga Toriello
Absolutely wonderful! It really helped tie together the various components, and stressed why knowing about the Krebs cycle is still important.


by Michael Schneider


by David Dominguez
Great Job. This was a wonderful conceptual overview! I wish I had this in medical school and pediatric residency! I am using this to study for my MOC recertification exam. Thanks! David

by Nazi Tabatadze

Simpe, easy and informative!

by Tinatin Tkemaladze
The course was super well organized. I loved the small video lectures, that were so easy to understand and remember! I is very well organized! Looking forward for the second tutorial!

Metabolism 102

by Reza Davoodi
You have spent lots of time to organize this lecture and you did such an excellent job. This type of lectures are very important for clinicians with little knowledge in metabolic diseases and/ or are not specialized in inborn errors of metabolism. Thank you for providing this educational materials for free as no one has any excuse not to watch these series of lectures.