Course Description

Course Title:

Metabolism 101: The metabolic crisis

Program Overview:

Many metabolic diseases are associated with acute clinical or biochemical decompensation, i.e., a metabolic crisis. This type of presentation is among the most characterized aspects of metabolic disease and also the most feared since such events represent true medical emergencies. However, crises also tend to occur in mostly treatable disorders. The clinical symptoms and signs of a crisis are outlined, along with a review of some classic disease phenotypes, and an approach for testing for a possible metabolic diagnosis.


Mark Korson, MD - Senior Medical Director - Genetic Metabolic Center for Education

Important Dates:

Valid Until: 12/01/2019
Date Released: 12/01/2016
Date Updated: 12/01/2016

Fee Statement:

This activity if FREE to all participants

Commercial Support:

This enduring internet activity has no commercial support

Learning Objectives:

1.Characterize the symptoms of a metabolic crisis

2.Describe the clinical scenarios in which catabolism is active

3.List the triggers that can set off a metabolic crisis

4.Identify the basic testing to order in the case where metabolic disease is a consideration

5.List the testing in a “metabolic screen

Disclosure Statement:

The information on this website is provided exclusively for educational purposes. Information about medicine is ever changing. As new research and clinical experience broadens knowledge, changes in treatment and procedures will be necessary.

Faculty Disclosure:

The listed speaker has no real or apparent conflict of interest to disclose.

Planning Committee Disclosure:

The members of the planning committee have no real or apparent conflict of interest to disclose.

Instruction for Completion:

To receive credit for this unit, view the video files and complete all survey questions. It will take approximately 60 minutes to complete. When you have finished, complete the post-test. Upon scoring at least 70% on the post-test and completion of the evaluation you will be able download your CME/CE certificate.

Clinicians who are not physicians will be provided a certificate of completion to submit for credit in accordance with their state nursing board, specialty society, or other professional association.

Additional Resources:

  • Inborn Metabolic Diseases, 5th Edition, Saudubray et al, eds. Springer Berlin Heidelberg, 2012
  • Vademecum Metabolicum, Diagnosis and Treatment of Inborn Errors of Metabolism, Zschocke J and Hoffman GF, eds. van Karnebeek C, e-ed. Downloadable app - eVm Mobile

MD, Senior Medical Director

Mark Korson

Dr. Mark Korson is Medical Director of the Genetic Metabolic Center for Education and is responsible for overseeing both the company’s consultative services and educational content together with a team of biochemical geneticists.Dr. Korson previously served as Metabolism Service Director (2000-2014) at Tufts Medical Center, where he launched the Metabolic Outreach Service to aid regional teaching hospitals lacking metabolic services. This program educated and advised non-metabolic clinicians, enabling greater participation in the care of metabolic patients.Since 2007, he has co-directed the North American Metabolic Academy, the premier training conference for genetic trainees on this continent, sponsored by the Society for Inherited Metabolic Disorders. He has given hundreds of lectures in the US and abroad, including Cyprus, Great Britain, Israel, Jordan, Malaysia, and most recently, the Republic of Georgia.Dr. Korson graduated from University of Toronto Medical School and completed pediatric residency at The Hospital for Sick Children. After a fellowship in genetics and metabolism in 1990 he directed the Metabolism Clinic until 2000 at Boston Children’s Hospital.

Course curriculum

  • 1

    DRAFT Tutorial introduction/objectives

    • DRAFT Tutorial 2 introduction and objectives

  • 2

    Pre-course assessment

    • Pre-course assessment

  • 3

    DRAFT Chapter 1: Defining a metabolic crisis

    • Symptoms of a metabolic crisis

    • Chapter 1 question 1

    • Symptoms of a metabolic crisis - continued

    • Sudden infant death syndrome - metabolic differential diagnosis

  • 4

    DRAFT Chapter 2: Metabolic triggers: stress

    • Acute metabolic disorders

    • Catabolic cascade

    • Example: organic acidemia

  • 5

    DRAFT Chapter 3: Metabolic triggers: diet

    • Causes and classification

    • Chapter 3 question 1

    • Example: hereditary fructose intolerance

  • 6

    DRAFT Chapter 4: Metabolic triggers: fasting

    • Causes and classification

    • Example: glycogen storage disease type I

    • Body response to fasting

    • Chapter 4 question

    • Example: glycogen storage disease type I continued

    • What triggers a metabolic crisis: questions to ask

  • 7

    DRAFT Chapter 5: Constructing a list of basic tests

    • Protein metabolism defects

    • Carbohydrate metabolism defects

    • Fatty acid oxidation defects

    • Routine lab tests to order

  • 8

    DRAFT Chapter 6: The clinical significance of basic testing

    • Blood gases and electrolytes

    • Chapter 6 question 1 (Brenda)

    • Chapter 6 question 2 (Eddie)

    • Blood gases and electrolytes continued

    • Urine ketones

    • Chapter 6 question 3

    • Ammonia

    • Liver function tests and CBC, differential

    • Glucose and lactate

  • 9

    DRAFT Chapter 7: Specific metabolic testing

    • Amino acids

    • Organic acids

    • Acylcarnitines

    • Example interpretations

  • 10

    DRAFT Chapter 8: Summary

    • Summary

  • 11

    Post-course evaluation

    • Post course evaluation

  • 12

    Essential slides for download

    • Metabolism 101 Tutorial 2 Essential slides

  • 13

    eLearning course survey

    • Course survey link


5 star rating

Excellent examples

Eleanor Ng

Yet another great module, I'm addicted to learning!

Yet another great module, I'm addicted to learning!

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5 star rating

Nino Epitashvili

5 star rating

An accurate title

Denise Fleming

Very clear

Very clear

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5 star rating

Nazi Tabatadze